منابع مشابه
Fixing a Hole in Lexicalized Plan Recognition
Previous work has suggested the use of lexicalized grammars for probabilistic plan recognition. Such grammars allow the domain builder to delay commitment to hypothesizing high level goals in order to reduce computational costs. However this delay has limitations. In the case of only partial observation traces, delaying commitment can prevent such algorithms from forming correct conclusions abo...
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A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment.
متن کاملEditorial commentary: Fixing a hole in the HIV safety net.
The fifth track on The Beatles’ iconic 1967 album Sgt. Pepper’s Lonely Hearts Club Band is a song entitled “Fixing a Hole.” In a 1968 interview, PaulMcCartney indicated that the song referenced “a hole in the road where rain gets in, a good old analogy—the hole in yourmake-up which lets the rain in and stops your mind from going where it will” [1]. For >2 decades, the Ryan White Care Act has be...
متن کاملFixing a Hole: Preventing Pneumococcal Pneumonia by Vaccination
The immune system of the human newborn is capable of responding to every microorganism or one of its components it encounters. In fact that is not true, there is one exception. The immune system of newborns is unable to respond to the capsular polysaccharides of bacteria such as Streptococcus pneumoniae. Because the immune system does not respond, S. pneumoniae can cause diseases such as pneumo...
متن کاملOn Marginal Automorphisms of a Group Fixing the Certain Subgroup
Let W be a variety of groups defined by a set W of laws and G be a finite p-group in W. The automorphism α of a group G is said to bea marginal automorphism (with respect to W), if for all x ∈ G, x−1α(x) ∈ W∗(G), where W∗(G) is the marginal subgroup of G. Let M,N be two normalsubgroups of G. By AutM(G), we mean the subgroup of Aut(G) consistingof all automorphisms which centralize G/M. AutN(G) ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1751rr5